Hypertension is the most common chronic disease, as well as cardio-cerebrovascular disease the main risk factors for stroke, myocardial infarction, heart failure and chronic kidney disease (CKD) is the main complication. Candesartan ester piece mainly of candesartan ester, is used in the treatment of essential hypertension. So, candesartan ester effect good? Mechanism of action is what?

Candesartan ester piece obtained good curative effect for the treatment of essential hypertension. The present study confirmed that patients with angiotensin increased myocyte hypertrophy and hyperplasia of fibroblasts and left ventricular hypertrophy, which can damage the function of left ventricular diastolic and systolic function. Inhibition of cell proliferation and accelerate cell apoptosis, against heart and vascular remodeling, delay or reverse myocardial hypertrophy, lower left ventricular mass index, improve heart function.

Candesartan ester is a new generation of Ang Ⅱ receptor blocker, in the research of diastolic heart failure in animal experiments found that candesartan ester can be by changing the function of calmodulin, phenotype changes of the collagen synthesis and accumulation of collagen cross-linking instead of antihypertensive effect, to reduce myocardial stiffness increased ventricular diastolic compliance purposes.

Candesartan ester in the body quickly be hydrolyzed into active metabolite candesartan, candesartan for selective angiotensin Ⅱ (AT1) receptor antagonist, by combined with vascular smooth muscle of AT1 receptor antagonist of angiotensin Ⅱ vasoconstriction, reducing peripheral vascular resistance. Another thought: candesartan can inhibit the adrenal glands secrete aldosterone and play a certain antihypertensive effect. Candesartan not restrain excited peptidase Ⅱ, does not affect the slow shock peptide degradation.

Saw the above introduction, believe everybody already knows of candesartan ester piece of efficacy and mechanism of action, if necessary, consult candesartan ester manufacturer sales staff, must be able to solve your problem. Hope these information can help to you.

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